Chronic Wound Infections
Failed treatment
Inadequate antibiotic levels at infection site
Inadequate antibiotic levels at infection site
Chronic wounds affect 2.5% of the US population, 43% due to infection. These patients have typically undergone weeks or months of antibiotic therapy without relief.
Inadequate antibiotic levels at infection site
Inadequate antibiotic levels at infection site
Inadequate antibiotic levels at infection site
Antibiotics are given orally, IV or IM (into muscle). The antibiotic spreads throughout the body and levels at the infection site, are often too low to combat the infection.
Antibiotics may also cause toxic side effects in other areas of the body.
Bacteria biofilm
Inadequate antibiotic levels at infection site
Bacteria biofilm
When bacteria infect an area, they secrete an extracellular matrix. Bacteria attach to the matrix creating a community or biofilm that has increased resistance to antibiotics and the immune system.